基本信息
姓 名：赵辉
学 位：博士
导师情况：博导、硕导
研究方向：药食同源天然产物
电子邮箱：zhaohui(at)tjcu.edu.cn
个人简介
Dr. Zhao received his MD in Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, where his research was focused on blood diseases. Afterward, he devoted his time to the investigation and clinical translation of stem cells. prevention of breast cancers. Since 2009, he joined Tianjin University of Commerce and began to be involved in naturally occurring compounds, mainly in dietary stilbenes and polymethoxylated flavones (PMFs) in citrus peel. Since then, his research was focused on the prevention of gastrointestinal damage and inflammation using these compounds, their parent raw materials. His research is documented in more than 100 peer-reviewed publications and book chapters.
主持的代表性科研项目
1、2018.4-2020.10 天津市高校中青年骨干项目
2、2016.1—2019.12 国家自然科学基金 陈皮黄酮抑制肠道菌群TMAO生成及预防动脉粥样硬化机理研究 学科代码:食品营养C200402 项目批准号: 31571832
3、2014.10-2016.9 天津市科委 建立基于荧光素酶报告基因为基础的蜂蜜功能食品开发生物学活性评价方法 项目批准号 14JCPJC00529
4、 2012.1-2015.12 国家自然科学基金 HIF-SCF-c-kit信号通路介导的肥大细胞参与食物肠道过敏反应机制研究负责人 学科代码：超敏反应性疾病(H1007) 项目批准号：81172837
代表性学术论文 (*通讯作者)
1. Jie Pan, Hui Zhao*, Liming Jia, Jinghua Jia, Jingning Jia, Yuhui Li, Qi Tang, Feiya Jiang, Liang Bai, Meiyan Wang, Yufeng Li*, Zheng Wang*. Protein hydrolysates from animal source food earthworm protect against dextran sulfate sodium (DSS)-induced intestinal barrier injury. Food Science and Human Wellness, 2025, 14(12): 9250618.
2. Peng B, Zhao H*, Yang F, Jie Pan, Liang Bai, Zhibo Han, Wenqiang Guan, Jianfu Liu, Yongqing Tao*, Zheng Wang*. Aluminum exposure-exacerbated experimental colitis in mice were antagonized by Pueraria lobata extract. Food Science and Human Wellness, 2025, 14(10): 9250423.
3. Lv K, Song J, Wang J, Zhao W, Yang F, Feiya J, Bai L, Guan W, Liu J, Ho CT, Li S*, Zhao H*, Wang Z*. Pterostilbene Alleviates Dextran Sodium Sulfate (DSS)-Induced Intestinal Barrier Dysfunction Involving Suppression of a S100A8-TLR-4-NF-κB Signaling Cascade. J Agric Food Chem. 2024 Aug 21;72(33):18489-18496.
4. Ke Lü, Xiaowan Song, Peng Zhang, Wei Zhao, Ning Zhang, Fan Yang, Wenqiang Guan, Jianfu Liu, He Huang, Chi-Tang Ho, Rong Di*, Hui Zhao*. Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice：a comparison with artificial sweetener aspartame. Food Science and Human Wellness. 2022; 11(4): 865-873.
5. Zhao W, Wang L*, Yang F, Zhang N, Fan J, Qin S, Shao T, Xu X, Yan S, Guo H, Li J, Zhao H*. Antioxidant activity assessment of Yingjisha sweet almond oil. The International Journal of Food Science & Technology. 2022 March, 57(3):1773-1781.
6. Wang J, Zhao H*, Lv K, Zhao W, Zhang N, Yang F, Wen X, Jiang X, Tian J, Liu X, Ho CT, Li S*. Pterostilbene Ameliorates DSS-Induced Intestinal Epithelial Barrier Loss in Mice via Suppression of the NF-κB-Mediated MLCK-MLC Signaling Pathway. J Agric Food Chem. 2021 Apr 7;69(13):3871-3878.
7. Wang L*, Brennan MA, Guan W, Liu J, Zhao H, Brennan CS*. Edible mushrooms dietary fibre and antioxidants: Effects on glycaemic load manipulation and their correlations pre-and post-simulated in vitro digestion. Food Chem. 2021 Jul 30;351:129320.
8. Wang M*, Zhao H, Wen X, Ho CT, Li S*. Citrus flavonoids and the intestinal barrier: Interactions and effects. Compr Rev Food Sci Food Saf. 2021 Jan;20(1):225-251.
9. Li M, Zhao H*, Wu J, Wang L, Wang J, Lv K, Liu S, Wang M, Guan W, Liu J, Ho CT, Li S*. Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes.J Agric Food Chem. 2020 Jul 8;68(27):7112-7120.
10. Wang L, Zhao H*, Brennan M, Guan W, Liu J, Wang M, Wen X, He J, Brennan C*. In vitro gastric digestion antioxidant and cellular radical scavenging activities of wheat-shiitake noodles. Food Chem. 2020 Nov 15;330:127214.
11. Wen X, Zhao H*, Wang L, Wang L, Du G, Guan W, Liu J, Cao X, Jiang X, Tian J, Wang M, H CT o, Li S*. Nobiletin Attenuates DSS-Induced Intestinal Barrier Damage through HNF4α-claudin-7 Signaling Pathway. J. Agric. Food Chem., 2020 Apr 22;68(16):4641-4649.
12. Wang L, Zhao H*, Wang L, Tao Y, Du G, Guan W, Liu J, Brennan C, Ho CT, Li S*. Effects of Selected Resveratrol Analogues on Activation and Polarization of Lipopolysaccharide-Stimulated BV-2 Microglial Cells. J Agric Food Chem. 2020 Mar 25;68(12):3750-3757.
13. Gao J, Liu J, Zhang L, Zhang Y, Guo Q, Li Y, Tong J, Wang H, Zhou J, Zhu F, Shi L*, Zhao H*. Heat shock transcription factor 1 regulates the fetal γ-globin expression in a stress-dependent and independent manner during erythroid differentiation. Exp Cell Res. 2020 Feb 15;387(2):111780.
14. Wu J, Li M, He J, Lv K, Wang M, Guan W, Liu J, Tao Y, Li S, Ho CT, Zhao H*. Protective effect of pterostilbene on concanavalin A-induced acute liver injury. Food Funct. 2019 Nov 1;10(11):7308-7314.
15. Zhang YS, Du G, Gao YT, Wang LW, Meng D, Li BJ, Brennan C, Wang MY, Zhao H,Wang SY, Guan WQ. The Effect of Carbonic Maceration during Winemaking on the Color, Aroma and Sensory Properties of 'Muscat Hamburg' Wine. Molecules. 2019 Aug 28;24(17). pii: E3120.
16. Yang G, Lin CC, Yang Y, Yuan L, Wang P, Wen X, Pan MH, Zhao H*, Ho CT, Li S*. Nobiletin Prevents Trimethylamine Oxide-Induced Vascular Inflammation via Inhibition of the NF-κB/MAPK Pathways. J Agric Food Chem. 2019 Jun 5; 67 (22):6169-6176.
17. Gao Y, Fang L, Wang X, Lan R, Wang M, Du G, Guan W, Liu J, Brennan M, Guo H, Brennan C, Zhao H*. Antioxidant Activity Evaluation of Dietary Flavonoid Hyperoside Using Saccharomyces Cerevisiae as a Model. Molecules. 2019 Feb 22; 24(4). pii: E788.
18. Jia B, Xu L, Guan W*, Lin Q, Brennan C, Yan R, Zhao H. Effect of citronella essential oil fumigation on sprout suppression and quality of potato tubers during storage. Food Chem. 2019 Jun 30; 284:254-258.
19. Wang L, Yang G, Yuan L, Yang Y, Zhao H, Ho CT, Li S*. Green Tea Catechins Effectively Altered Hepatic Fibrogenesis in Rats by Inhibiting ERK and Smad1/2 Phosphorylation. J Agric Food Chem. 2019 May 15; 67(19):5437-5445.
20. Liu J, Li Y, Tong J, Gao J, Guo Q, Zhang L, Wang B, Zhao H, Wang H, Jiang E, Kurita R, Nakamura Y, Tanabe O, Engel JD, Bresnick EH, Zhou J, Shi L*. Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development. Nat Commun. 2018 Oct 22; 9(1):4386.
21. Yang G, Li S, Yang Y, Yuan L, Wang P, Zhao H, Ho CT, Lin CC*. Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4(+) T Cells through Mitogen-Activated Protein Kinase Signaling Pathways. J Agric Food Chem. 2018 Aug 8; 66(31):8299-8306.
22. L Bai, X Cheng, J Xu, X Wang, H Zhao, Y Tao*, H Huang*. Black sesame pigment extract from sesame dregs by subcritical CO2: Extraction optimization, composition analysis, binding copper and antioxidant protection. LWT, 2019, 100 (2):28-34
23. Wang M, Meng D, Zhang P, Wang X, Du G, Brennan C, Li S*, Ho CT, Zhao H*. Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae. J Agric Food Chem. 2018, 66 (12):3155–3160
24. Zhang L, Wen X, Li M, Li S*, Zhao H*. Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene. Biofactors. 2018 Jan; 44(1):61-68.
25. Wang L, Pan MH, Lo CY, Zhao H, Li S, Ho CT, Yang G. Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation. Food Funct. 2018 Feb 21; 9(2):951-958.
26. Ma J, Gong W, Liu S, Li Q, Guo M, Wang J, Wang S, Chen N, Wang Y, Liu Q, Zhao H*. Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3. Tumour Biol. 2018 Jan;40(1):1010428317731369. doi:10.1177/1010428317731369.
27. Ji K, Fang L, Zhao H, Li Q, Shi Y, Xu C, Wang Y, Du L, Wang J, Liu Q. Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells. Oxid Med Cell Longev.2017;2017:1480294.
28. Pan P, Skaer C, Yu J, Zhao H, Ren H, Oshima K, Wang LS. Berries and other natural products in the pancreatic cancer chemoprevention in human clinicaltrials. J Berry Res. 2017;7(3):147-161.
29. Wang J, Wang L, Ho CT, Zhang K, Liu Q, Zhao H*. Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation. J Agric Food Chem. 2017;65(18):3675-3683.
30. Meng D, Zhang P, Ho CT, Li S*, Zhao H*. Antioxidant activity evaluation of dietary phytochemicals using Saccharomyces cerevisiae as a model. Journal of Functional Foods. 2017；38:36-44
31. Meng D, Zhang P, Zhang L, Wang H, Ho CT, Li S*, Shahidi F, Zhao H*. Detection of cellular redox reactions and antioxidant activity assays. Journal of Functional Foods. 2017;37:467-479
32. Jinhan Wang, Ming Yao, Yan Wang, Chi-Tang Ho, Shiming Li, Yang Shi, Qiang Liu, Hui Zhao*. 6-Shogaol Ameliorates Injury to the Intestinal Mucosa and Increases Survival After High-dose Abdominal Irradiation. Journal of Functional Foods.2017; 36:63-71.
代表性专利
1、 PH值测试液及其制备方法（CN104237229B）
2、 一种利用高压溶剂提取橘皮中有效成分的方法及装置（CN103173285B）
3、 雪菊提取物及雪菊总黄酮在制备治疗肝纤维化药物的应用 (CN105641011B)
4、 超临界二氧化碳法提取的益智挥发油在制备改善炎症性肠病的药物中的应用 (CN 117959398 B)
获奖
1、2013年 脐血间充质干细胞对脑损伤的修复机制 河北省科学技术进步三等奖（2013JB3032-4）
2、2011年 肿瘤细胞辐射敏感性预测方法的建立及其应用 天津市科学技术进步二等奖（2011JB-2-022-R6）
3、2010年 脐带间充质干细胞生物学特性和规模化制备与保存技术天津市滨海新区技术发明奖一等奖（2010BHFM-1-002）
4、2008年 血管干细胞与促血管新生的基础及临床应用研究 中华人民共和国教育部科技进步二等奖（2007-267）
