赵辉
一、个人概况
赵辉，性别：男；学历：博士；职称：高级工程师（生物制药）
毕业院校：中国医学科学院协和医科大学
通讯地址：天津商业大学 生物技术与食品工程学院 制药工程系
E-mail: zhaohui@tjcu.edu.cn
研究方向：药食同源天然产物基础与营养开发
二、学习教育经历
2014.08-2015.02 美国Rutgers大学植物病理系、食品科学系访问学者
2000.09-2005.06 中国医学科学院协和医科大学 硕博连读，医学博士
1992.09-1997.06 华北煤炭医学院临床医学系，医学学士
三、工作经历
1997.06—2000.08 华北煤炭医学院附属医院儿科 住院医师
2000.09—2005.06 中国医学科学院协和医科大学血液学研究所血液病医院 血液学基础与临床
2005.07---2009.10 细胞产品国家工程研究中心临床前研发部主任
2009.11-现在 天津商业大学生物技术与食品科学学院制药工程系 天然产物与食物功能成分和营养
四、获奖情况
2013年 脐血间充质干细胞对脑损伤的修复机制 河北省科学技术进步三等奖（2013JB3032-4）
2011年 肿瘤细胞辐射敏感性预测方法的建立及其应用 天津市科学技术进步二等奖（2011JB-2-022-R6）
2010年 脐带间充质干细胞生物学特性和规模化制备与保存技术天津市滨海新区技术发明奖一等奖（2010BHFM-1-002）
2008年 血管干细胞与促血管新生的基础及临床应用研究 中华人民共和国教育部科技进步二等奖（2007-267）
五、社会兼职
Journal of Food Bioactives杂志编委 （Editorial Board ）
Food Science and Human Wellness 杂志编委 （Editorial Board ）
天津市细胞生物学会 理事
天津市医疗健康学会 研究创新专委会 主任委员
六、近三年来发表文章（*通讯作者）
1.Wang J, Zhao H*, Lv K, Zhao W, Zhang N, Yang F, Wen X, Jiang X, Tian J, Liu X, Ho CT, Li S*. Pterostilbene Ameliorates DSS-Induced Intestinal Epithelial Barrier Loss in Mice via Suppression of the NF-κB-Mediated MLCK-MLC Signaling Pathway. J Agric Food Chem. 2021 Apr 7;69(13):3871-3878.
2.Wang L*, Brennan MA, Guan W, Liu J, Zhao H, Brennan CS*. Edible mushrooms dietary fibre and antioxidants: Effects on glycaemic load manipulation and their correlations pre-and post-simulated in vitro digestion. Food Chem. 2021 Jul 30;351:129320.
3.Wang M*, Zhao H, Wen X, Ho CT, Li S*. Citrus flavonoids and the intestinal barrier: Interactions and effects. Compr Rev Food Sci Food Saf. 2021 Jan;20(1):225-251.
4.Li M, Zhao H*, Wu J, Wang L, Wang J, Lv K, Liu S, Wang M, Guan W, Liu J, Ho CT, Li S*.Nobiletin Protects against Acute Liver Injury via Targeting c-Jun N-Terminal Kinase (JNK)-Induced Apoptosis of Hepatocytes.J Agric Food Chem. 2020 Jul 8;68(27):7112-7120.
5.Wang L, Zhao H*, Brennan M, Guan W, Liu J, Wang M, Wen X, He J, Brennan C*.In vitro gastric digestion antioxidant and cellular radical scavenging activities of wheat-shiitake noodles. Food Chem. 2020 Nov 15;330:127214.
6.Wen X, Zhao H*, Wang L, Wang L, Du G, Guan W, Liu J, Cao X, Jiang X, Tian J, Wang M, H CT o, Li S*. Nobiletin Attenuates DSS-Induced Intestinal Barrier Damage through HNF4α-claudin-7 Signaling Pathway. J. Agric. Food Chem., 2020 Apr 22;68(16):4641-4649.
7.Wang L, Zhao H*, Wang L, Tao Y, Du G, Guan W, Liu J, Brennan C, Ho CT, Li S*. Effects of Selected Resveratrol Analogues on Activation and Polarization of Lipopolysaccharide-Stimulated BV-2 Microglial Cells. J Agric Food Chem. 2020 Mar 25;68(12):3750-3757.
8.Gao J, Liu J, Zhang L, Zhang Y, Guo Q, Li Y, Tong J, Wang H, Zhou J, Zhu F, Shi L*, Zhao H*. Heat shock transcription factor 1 regulates the fetal γ-globin expression in a stress-dependent and independent manner during erythroid differentiation. Exp Cell Res. 2020 Feb 15;387(2):111780..
9.Wu J, Li M, He J, Lv K, Wang M, Guan W, Liu J, Tao Y, Li S, Ho CT, Zhao H*. Protective effect of pterostilbene on concanavalin A-induced acute liver injury. Food Funct. 2019 Nov 1;10(11):7308-7314.
10.Zhang YS, Du G, Gao YT, Wang LW, Meng D, Li BJ, Brennan C, Wang MY, Zhao H,Wang SY, Guan WQ. The Effect of Carbonic Maceration during Winemaking on the Color, Aroma and Sensory Properties of 'Muscat Hamburg' Wine. Molecules. 2019 Aug 28;24(17). pii: E3120.
11.Yang G, Lin CC, Yang Y, Yuan L, Wang P, Wen X, Pan MH, Zhao H*, Ho CT, Li S*. Nobiletin Prevents Trimethylamine Oxide-Induced Vascular Inflammation via Inhibition of the NF-κB/MAPK Pathways. J Agric Food Chem. 2019 Jun 5; 67 (22):6169-6176.
12.Gao Y, Fang L, Wang X, Lan R, Wang M, Du G, Guan W, Liu J, Brennan M, Guo H, Brennan C, Zhao H*. Antioxidant Activity Evaluation of Dietary Flavonoid Hyperoside Using Saccharomyces Cerevisiae as a Model. Molecules. 2019 Feb 22; 24(4). pii: E788.
13.Jia B, Xu L, Guan W, Lin Q, Brennan C, Yan R, Zhao H. Effect of citronella essential oil fumigation on sprout suppression and quality of potato tubers during storage. Food Chem. 2019 Jun 30; 284:254-258.
14.Wang L, Yang G, Yuan L, Yang Y, Zhao H, Ho CT, Li S*. Green Tea Catechins Effectively Altered Hepatic Fibrogenesis in Rats by Inhibiting ERK and Smad1/2 Phosphorylation. J Agric Food Chem. 2019 May 15; 67(19):5437-5445.
15.Liu J, Li Y, Tong J, Gao J, Guo Q, Zhang L, Wang B, Zhao H, Wang H, Jiang E, Kurita R, Nakamura Y, Tanabe O, Engel JD, Bresnick EH, Zhou J, Shi L*. Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development. Nat Commun. 2018 Oct 22; 9(1):4386.
16.Yang G, Li S, Yang Y, Yuan L, Wang P, Zhao H, Ho CT, Lin CC*. Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4(+) T Cells through Mitogen-Activated Protein Kinase Signaling Pathways. J Agric Food Chem. 2018 Aug 8; 66(31):8299-8306.
17.L Bai, X Cheng, J Xu, X Wang, H Zhao, Y Tao*, H Huang*. Black sesame pigment extract from sesame dregs by subcritical CO2: Extraction optimization, composition analysis, binding copper and antioxidant protection. LWT, 2019, 100 (2):28-34
18.Wang M, Meng D, Zhang P, Wang X, Du G, Brennan C, Li S*, Ho CT, Zhao H*. Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae. J Agric Food Chem. 2018, 66 (12):3155–3160
19.Zhang L, Wen X, Li M, Li S*, Zhao H*. Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene. Biofactors. 2018 Jan; 44(1):61-68.
20.Wang L, Pan MH, Lo CY, Zhao H, Li S, Ho CT, Yang G. Anti-fibrotic activity of polyphenol-enriched sugarcane extract in rats via inhibition of p38 and JNK phosphorylation. Food Funct. 2018 Feb 21; 9(2):951-958.
21.Ma J, Gong W, Liu S, Li Q, Guo M, Wang J, Wang S, Chen N, Wang Y, Liu Q, Zhao H*. Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3. Tumour Biol. 2018 Jan;40(1):1010428317731369. doi:10.1177/1010428317731369.
22.Ji K, Fang L, Zhao H, Li Q, Shi Y, Xu C, Wang Y, Du L, Wang J, Liu Q. Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells. Oxid Med Cell Longev.2017;2017:1480294.
23.Pan P, Skaer C, Yu J, Zhao H, Ren H, Oshima K, Wang LS. Berries and other natural products in the pancreatic cancer chemoprevention in human clinicaltrials. J Berry Res. 2017;7(3):147-161.
24.Wang J, Wang L, Ho CT, Zhang K, Liu Q, Zhao H*. Garcinol from Garcinia indica Downregulates Cancer Stem-like Cell Biomarker ALDH1A1 in Nonsmall Cell Lung Cancer A549 Cells through DDIT3 Activation. J Agric Food Chem. 2017;65(18):3675-3683.
25.Meng D, Zhang P, Ho CT, Li S*, Zhao H*. Antioxidant activity evaluation of dietary phytochemicals using Saccharomyces cerevisiae as a model. Journal of Functional Foods. 2017；38:36-44
26.Meng D, Zhang P, Zhang L, Wang H, Ho CT, Li S*, Shahidi F, Zhao H*. Detection of cellular redox reactions and antioxidant activity assays. Journal of Functional Foods. 2017;37:467-479
27.Jinhan Wang, Ming Yao, Yan Wang, Chi-Tang Ho, Shiming Li, Yang Shi, Qiang Liu, Hui Zhao*. 6-Shogaol Ameliorates Injury to the Intestinal Mucosa and Increases Survival After High-dose Abdominal Irradiation. Journal of Functional Foods.2017; 36:63-71.
七、近三年获得授权的发明专利
1. PH值测试液及其制备方法（CN104237229B）.
2. 一种利用高压溶剂提取橘皮中有效成分的方法及装置（CN103173285B）.
3. 雪菊提取物及雪菊总黄酮在制备治疗肝纤维化药物的应用 (CN105641011B)
八、近年来项目情况（不包括横向课题）
2018.4-2020.10 天津市高校中青年骨干项目
2016.1—2019.12 国家自然科学基金 陈皮黄酮抑制肠道菌群TMAO生成及预防动脉粥样硬化机理研究 学科代码:食品营养C200402 项目批准号: 31571832
2014.10-2016.9 天津市科委 建立基于荧光素酶报告基因为基础的蜂蜜功能食品开发生物学活性评价方法 项目批准号 14JCPJC00529
2012.1-2015.12 国家自然科学基金 HIF-SCF-c-kit信号通路介导的肥大细胞参与食物肠道过敏反应机制研究负责人 学科代码：超敏反应性疾病(H1007) 项目批准号：81172837
