基本信息:裴醒,女,讲师,生物技术与食品科学学院,硕士生导师
教育背景:2021-2023:天津医科大学基础医学院 博士后
2016-2021:天津医科大学药学院 药理学博士
2017-2018:韩国梨花女子大学药学院 交流访问
2012-2016:天津医科大学药学院 药物制剂学士
联系方式:peixing@tjcu.edu.cn,4号实验楼614室
招生方向:1.食品科学与工程;2.生物与医药
学科领域:
1.药食同源功能因子的递送及生物活性评价
2.智能药物递释系统的构建及应用
代表性论文:
1、Xing Pei, Xiaojuan Zhang, Lu Zhang, Jingwen Zhao, Mengmeng Yuan, Lu Sun, Fei Yu, Bangmao Wang, Jingwen Zhao*, Huining He, Victor C. Yang. Targeted Exosomes for Co-delivery of siFGL1 and siTGF-β1 for Combined Cancer Immunotherapy. Chemical Engineering Journal, 421:129774, 2021. SCI, IF 13.273. 1区TOP.
2、Xing Pei, Heejung Kim1, Minjoo Lee, Nana Wang, Jiyoung Shin, Seungjin Lee, Miyun Yoon, Victor C. Yang, Huining He. Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model. Journal of Controlled Release, 322:610–621, 2020. SCI, IF: 9.776. 1区TOP.
3、Xing Pei, Jiyoung Shin, Heejung Kim, Nana Wang, Chaewon Seo, Miyun Yoon, Xiongwen Chen, Jianqing Gao, Victor C. Yang, Huining He, Seungjin Lee. Cardiac-derived stem cell engineered with constitutively active HIF-1α gene enhances blood perfusion of hindlimb ischemia. Journal of Industrial and Engineering Chemistry, 105:210-221, 2022. SCI, IF: 6.76. 2区.
4、Junxiao Ye, Xing Pei, Hui Cui, Zhili Yu, Hyukjin Lee, Jianxin Wang, Xu Wang, Lu Sun, Huining He, Victor C. Yang. Cellular uptake mechanism and comparative in vitro cytotoxicity studies of monomeric LMWP-siRNA conjugate. Journal of Industrial and Engineering Chemistry, 63:103-111, 2018. SCI, IF: 4.978. 2区.
5、Zhili Yu, Xiaojuan Zhang, Xing Pei, Weiran Cao, Junxiao Ye, Jianxin Wang, Lu Sun, Fei Yu, Jiancheng Wang, Nan Li, Kyuri Lee, Stefan Barth, Victor C. Yang, Huining He. Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA. International Journal of Pharmaceutics,2021, 606: 120940. SCI, IF: 5.875. 2区TOP.
6、Junxiao Ye , Hui Cui , Ergang Liu , Xing Pei, Meihong Chai , Lu Sun, Dongmei Wang, Victor C Yang, Fei Yu. Temperature switchable linkers suitable for triggered drug release in cancer thermo-chemotherapy. International Journal of Pharmaceutics, 2024, 666: 124757. SCI, IF: 5.3. 2区TOP.
科研项目:
1、国家自然科学基金青年项目,"多级靶向MSC源性外泌体共载siPKA与依达拉奉协同治疗心肌缺血再灌注损伤的研究" (82300336),2024.01-2026.12,在研,主持;
2、天津商业大学科研启动项目,心脏靶向外泌体递送系统的构建与应用,2023-2026,在研,主持;
3、国家自然科学基金面上项目,"抑制脑胶质瘤术后复发的多功能外泌体-温敏凝胶原位药物递释系统研究" (82173769),2022.01-2025.12,在研,参与;
4、国家自然科学基金面上项目,"腺相关病毒介导的肺动脉高压引起的右心室心衰的基因治疗研究" (82070428),2021.01-2024.12,在研,参与;
5、国家重点研发计划-政府间国际科技创新合作,"白血病特定亚型精准免疫治疗的高效核酸药物体系研究" (SQ2019YFE012044),2021-2023,结题,参与;
获奖成果:
多肽介导的蛋白药物递释系统,天津市自然科学奖三等奖,2024
核酸药物递送系统及其应用,第二届博士后创新创业大赛银奖,2023
团队成员:张彦青